Publications: 2005-2007 Publications: 2003-2004 Publications: 2000-2002 Publications: 1997-1999 Pubs by Keyword Pubs by First Author Many of the papers in this section are available on PubMed. Click on the logo below for PubMed. Copyright © 2004-2007 Massachusetts General Hospital

The following is a listing of publications from 1997 through the present by keyword. Articles may be listed under more than one keyword. Acetylcholine Fiber atrophy, but not changes in acetylcholine receptor expression, contributes to the muscle dysfunction after immobilization Ibebunjo C, Martyn JA. Crit Care Med. 27 :275-85, 1999 Na+ channel and acetylcholine receptor changes in muscle at sites distant from burns do not simulate denervation Nosek MT, Martyn JA. J Appl Physiol. 82 :1333-9, 1997 Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression Shin YS, Fink H, Khiroya R, Ibebunjo C, Martyn J. Anesth Analg. 91:322-8, 2000 Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors Fink H, Luppa P, Mayer B, Rosenbrock H, Metzger J, Martyn JA, Blobner M. Anesthesiology. 98 : 82-8, 2003 American Burn Association Presidential Address - The American Burn Association in the New Millennium Tompkins RG. J Burn Care Rehabil. 22:369-374, 2001 Amino Acids: Metabolism and Requirement Daily requirement for total sulfur amino acids of chronically undernourished Indian men Kurpad AV, Regan MM, Varalakshmi S, Gnanou J, Young VR. Am J Clin Nutr. 2004 Jul;80(1):95-100 Dietary requirements for indispensable amino acids in adult humans: new concepts, methods of estimation, uncertainties and challenges Metges CC, Petzke KJ, Young VR. Ann Nutr Metab. 43:267-76, 1999 Got some amino acids to spare? Young VR. Am J Clin Nutr. 74:709-11, 2001 Introduction to the 3rd Amino Acid Assessment Workshop Cynober L, Young VR. J Nutr. 2004 Jun;134(6 Suppl):1555S-1557S Inverse relationship between protein intake and plasma free amino acids in healthy men at physical exercise Forslund AH, Hambraeus L, van Beurden H, Holmback U, El-Khoury AE, Hjorth G, Olsson R, Stridsberg M, Wide L, Akerfeldt T, Regan M, Young VR. Am J Physiol Endocrinol Metab. 278:E857-67, 2000 Nitrogen and amino acid requirements: the Massachusetts Institute of Technology amino acid requirement pattern Young VR, Borgonha S. J Nutr. 130:1841S-9S, 2000 Proteins, peptides and amino acids in enteral nutrition: overview and some research challenges Young VR, Yu YM, Borgonha S. Nestle Nutr Workshop Ser Clin Perform Programme. 3:1-20; discussion 20-3, 2000 Stimulation of rat hepatic amino acid transport by burn injury Lohmann R, Souba WW, Zakrzewski K, Bode BP. Metabolism. 47 :608-16, 1998 Twenty-four-hour L[1-13C]tyrosine and L-[3,3-2H2]phenylalanine oral tracer studies at generous, "requirement" and low phenylalanine intakes, to estimate aromatic amino acid requirement in adults Basile-Filho A, Beaumier L, El-Khoury AE, Yu Y-M, Kenneway M, Gleason RE, Young VR. Am J Clin Nutr 67: 640-659, 1998 Amino Acids: Arginine Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients Lau T, Owen W, Yu YM, Noviski N, Lyons J, Zurakowski D, Tsay R, Ajami A, Young VR, Castillo L. J Clin Invest. 105:1217-25, 2000 Arginine and nitric oxide metabolism in critically ill septic pediatric patients Argaman Z, Young VR, Noviski N, Castillo-Rosas L, Lu XM, Zurakowski D, Cooper M, Davison C, Tharakan JF, Ajami A, Castillo L. Crit Care Med. 31 :591-7, 2003 Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal Yu YM, Ryan CM, Castillo L, Lu XM, Beaumier L, Tompkins RG, Young VR. Am J Physiol Endocrinol Metab. 280:E509-17, 2001 L-arginine transport in the human coronary and peripheral circulation Miner SE, Al-Hesayen A, Kelly S, Benson T, Thiessen JJ, Young VR, Parker JD. Circulation. 2004 Mar 16;109(10):1278-83. Epub 2004 Mar 08 Metabolic fate of extrahepatic arginine in liver after burn injury. Chen CL. Fei Z. Carter EA. Lu XM. Hu RH. Young VR. Tompkins RG. Yu YM. Metabolism: Clinical & Experimental. 52(10):1232-9, 2003 Oct. Amino Acids: Asparagine Asparagine uptake in rat hepatocytes: resolution of a paradox and insights into substrate-dependent transporter regulation Pawlik TM, Souba WW, Bode BP. Amino Acids. 20:335-52, 2001 Amino Acids: Creatine Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states Louis M, Poortmans JR, Francaux M, Hultman E, Berre J, Boisseau N, Young VR, Smith K, Meier-Augenstein W, Babraj JA, Waddell T, Rennie MJ. Am J Physiol 284 :E764-70, 2003 Amino Acids: Cysteine and Homocysteine Cysteine kinetics and oxidation at different intakes of methionine and cysteine in young adults Raguso CA, Regan MM, Young VR. Am J Clin Nutr. 71:491-9, 2000 Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients Lyons J, Rauh-Pfeiffer A, Ming-Yu Y, Lu XM, Zurakowski D, Curley M, Collier S, Duggan C, Nurko S, Thompson J, Ajami A, Borgonha S, Young VR, Castillo L. Crit Care Med. 29:870-7, 2001 Homocysteine impairs coronary microvascular dilator function in humans Tawakol A, Forgione MA, Stuehlinger M, Alpert NM, Cooke JP, Loscalzo J, Fischman AJ, Creager MA, Gewirtz H. J Am Coll Cardiol. 40:1051-58, 2002 Amino Acids: Glutamate and Glutamine Glutamate: an amino acid of particular distinction Young VR, Ajami AM. J Nutr. 130(4S Suppl):892S-900S, 2000 Glutamine: the emperor or his clothes? Young VR, Ajami AM. J Nutr 131(9 Suppl):2449S-59S, 2001 Hepatic glutamine transporter activation in burn injury: role of amino acids and phosphatidylinositol-3-kinase Pawlik TM, Lohmann R, Souba WW, Bode BP. Am J Physiol 278:G532-41, 2000 Induction of glutamine synthetase expression after major burn injury is tissue specific and temporally variable Abcouwer SF, Lohmann R, Bode BP, Lustig RJ, Souba WW. J Trauma. 42 :421-7; discussion 427-8, 1997 Short-term enteral glutamine does not enhance protein accretion in burned children: a stable isotope study Sheridan RL, Prelack K, Yu YM, Lydon M, Petras L, Young VR, Tompkins RG. Surgery. 2004 Jun;135(6):671-8 Amino Acids: Glutathione and Oxoproline Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet Lyons J, Rauh-Pfeiffer A, Yu YM, Lu XM, Zurakowski D, Tompkins RG, Ajami AM, Young VR, Castillo L. Proc Natl Acad Sci U S A. 97:5071-6, 2000 Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans Yu YM, Ryan CM, Fei ZW, Lu XM, Castillo L, Schulz JT, Tompkins RG, Young VR. American Journal of Physiology-Endocrinology & Metabolism. 282:E247-58, 2002 Oxoproline kinetics and oxoproline urinary excretion during glycine- or sulfur amino acid-free diets in humans Metges CC, Yu YM, Cai W, Lu XM, Wong S, Regan MM, Ajami A, Young VR. Am J Physiol Endocrinol Metab. 278:E868-76, 2000 Amino Acids: Leucine Daily requirement for and splanchnic uptake of leucine in healthy adult Indians Kurpad AV, Raj T, El-Khoury A, Kuriyan R, Maruthy K, Borgonha S, Chandukudlu D, Regan MM, Young VR. Am J Clin Nutr. 74(6):747-55, 2001 Kinetics of L-[1-13C]leucine when ingested with free amino acids, unlabeled or intrinsically labeled casein Metges CC, El-Khoury AE, Selvaraj AB, Tsay RH, Atkinson A, Regan MM, Bequette BJ, Young VR. Am J Physiol Endocrinol Metab. 278:E1000-9, 2000 Leucine requirement and splanchnic uptake of leucine in chronically undernourished adult Indian subjects Kurpad AV, Regan MM, Raj T, Varalakshmi S, Gnanou J, Thankachan P, Young VR. Am J Clin Nutr. 2003 Apr;77(4):861-7 Rates of urea production and hydrolysis and leucine oxidation change linearly over widely varying protein intakes in healthy adults Young VR, El-Khoury AE, Raguso CA, Forslund AH, Hambraeus L. J Nutr. 130:761-6, 2000 The 24-h whole body leucine and urea kinetics at normal and high protein intakes with exercise in healthy adults Forsland AH, Hambraeus L, Olsson RM, El-Khoury AE, Yu Y-M, Young VR. Am J Physiol 275: E310-E320, 1998 Amino Acids: Lysine Intestinal parasites increase the dietary lysine requirement in chronically undernourished Indian men Kurpad AV, Regan MM, Nazareth D, Nagaraj S, Gnanou J, Young VR. Am J Clin Nutr. 2003 Dec;78(6):1145-51 (AA) Lysine requirements of healthy adult Indian subjects, measured by an indicator amino acid balance technique Kurpad AV, Raj T, El-Khoury A, Beaumier L, Kuriyan R, Srivatsa A, Borgonha S, Selvaraj A, Regan MM, Young VR. Am J Clin Nutr. 73:900-7, 2001 Twenty-four-hour oral tracer studies with L-[1-13C]lysine at a low (15 mg • kg-1 • d-1) and intermediate (29 mg • kg-1 • d-1) lysine intake in healthy adults El-Khoury AE, Pereira PC, Borgonha S, Basile-Filho A, Beaumier L, Wang SY, Metges CC, Ajami AM, Young VR. Am J Clin Nutr. 72:122-30, 2000 What is apparent is not always real: lessons from lysine requirement studies in adult humans Kurpad AV, Young VR. J Nutr. 2003 Apr;133(4):1227-30 Amino Acids: Metabolism and Requirements Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements Antoniewicz MR, Kelleher JK, Stephanopoulos G Metab Eng. 8(4):324-37, 2006 Jul. Amino Acids: Methylhistidine Negative chemical ionization gas chromatography/mass spectrometry to quantify urinary 3-methylhistidine: application to burn injury Beffa DC, Carter EA, Lu XM, Yu YM, Prelack K, Sheridan RL, Young VR, Fischman AJ, Tompkins RG. Anal Biochem. 355(1):95-101, 2006 Aug 1. Amino Acids: Methionine Daily methionine requirements of healthy Indian men, measured by a 24-h indicator amino acid oxidation and balance technique Kurpad AV, Regan MM, Varalakshmi S, Vasudevan J, Gnanou J, Raj T, Young VR. Am J Clin Nutr. 2003 May;77(5):1198-205 Apoptosis Adipocyte apoptosis after burn injury is associated with altered fat metabolism Yasuhara S, Kaneki M, Sugita H, Sugita M, Asai A, Sahani N, Chon JY, Tompkins RG, Martyn JA J Burn Care Res. 27(3):367-76, 2006 May-Jun. Apoptosis in critical illness Lydon A, Martyn JA. Int Anesthesiol Clin. 41:65-77, 2003 Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats Yasuhara S, Kanakubo E, Perez ME, Kaneki M, Fujita T, Okamoto T, Martyn JA. The 1999 Moyer award. J Burn Care Rehabil. 20 :462-70, 1999 Id2 expression during apoptosis and satellite cell activation in unloaded and loaded quail skeletal muscles Alway SE, Martyn JK, Ouyang J, Chaudhrai A, Murlasits ZS. Am J Physiol 284 :R540-9, 2003 Skeletal muscle apoptosis after burns is associated with activation of proapoptotic signals Yasuhara S, Perez ME, Kanakubo E, Yasuhara Y, Shin YS, Kaneki M, Fujita T, Martyn JA. Am J Physiol Endocrinol Metab. 279:E1114-21, 2001 Artificial Skin Artificial skin Schulz JT 3rd, Tompkins RG, Burke JF. Annu Rev Med. 51:231-44, 2000 Initial experience with a composite autologous skin substitute Sheridan RL, Morgan JR, Cusick JL, Petras LM, Lydon MM, Tompkins RG. Burns. 27 :421-4, 2001 Bacterial Virulence Plants and animals share functionally common bacterial virulence factors Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG. Proc Natl Acad Sci U S A. 97:8815-21, 2000 Camptothecin Synthesis of a macromolecular camptothecin conjugate with dual phase drug release Yurkovetskiy AV. Hiller A. Syed S. Yin M. Lu XM. Fischman AJ. Papisov MI. Mol Pharm. 1(5):375-82, 2004 Sep-Oct. CNK1 The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B. J Biol Chem. 2004 Jul 9;279(28):29247-54 Depression Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression Dougherty DD, Weiss AP, Cosgrove GR, Alpert NM, Cassem EH, Nierenberg AA, Price BH, Mayberg HS, Fischman AJ, Rauch SL. J Neurosurg. 2003 Dec;99(6):1010-7 d-Tubocurarine Mechanisms for the paradoxical resistance to d-tubocurarine during immobilization-induced muscle atrophy Ibebunjo C, Nosek MT, Itani MS, Martyn JA. J Pharmacol Exp Ther. 283:443-51, 1997 Thermal injury induces greater resistance to d-tubocurarine in local rather than in distant muscles in the rat Ibebunjo C, Martyn JA. Anesth Analg. 91:1243-9, 2000 E. Coli Localization of radiolabeled chemotactic peptide at focal sites of Escherichia coli infection in rabbits: evidence for a receptor-specific mechanism Babich JW, Tompkins RG, Graham W, Barrow SA, Fischman AJ. J Nucl Med. 38:1316-22, 1997 Fibrinogen Acute changes in fibrinogen metabolism and coagulation after hemorrhage in pigs Martini WZ, Chinkes DL, Pusateri AE, Holcomb JB, Yu YM, Zhang XJ, Wolfe RR Am J Physiol Endocrinol Metab. 289(5):E930-4, 2005 Nov Glucocorticoids Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells Yasukawa T, Kaneki M, Yasuhara S, Lee SL, Martyn JA. Anesthesiology. 2004 Jun;100(6):1615-9 Glucose Oxidation Maximal parenteral glucose oxidation in hypermetabolic young children: a stable isotope study Sheridan RL, Yu YM, Prelack K, Young VR, Burke JF, Tompkins RG. JPEN 22 :212-6, 1998 Hippocampus Hippocampal function in posttraumatic stress disorder Shin LM, Shin PS, Heckers S, Krangel TS, Macklin ML, Orr SP, Lasko N, Segal E, Makris N, Richert K, Levering J, Schacter DL, Alpert NM, Fischman AJ, Pitman RK, Rauch SL. Hippocampus. 2004;14(3):292-300 Insulin/Insulin Resistance Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA. J Biol Chem. 272 :25289-95, 1997 Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, Martyn JA Am J Physiol Endocrinol Metab. 288(3):E585-91, 2005 Mar. Immobilization depresses insulin signaling in skeletal muscle Hirose M, Kaneki M, Sugita H, Yasuhara S, Martyn JA. Am J Physiol Endocrinol Metab. 279:E1235-41, 2001 Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M J Biol Chem. 280(14):14203-11, 2005 Apr 8. Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, Martyn JA. Am J Physiol Endocrinol Metab. 282:E386-94, 2002 Insulin resistance in burns and trauma Carter EA. Nutr Rev. 56 :S170-6, 1998 Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue Carter EA, Burks D, Fischman AJ, White M, Tompkins RG. Int J Mol Med. 2004 Oct;14(4):653-8 Long-term denervation impairs insulin receptor substrate-1-mediated insulin signaling in skeletal muscle Hirose M, Kaneki M, Sugita H, Yasuhara S, Ibebunjo C, Martyn JA, Iebunjo C. Metabolism. 50:216-22, 2001 Mechanism of suppression of insulin signaling with lignocaine Hirose M, Martyn JA, Kuroda Y, Marunaka Y, Tanaka Y. Br J Pharmacol. 136:76-80, 2002 Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG Life Sci. 77(24):3068-77, 2005 Oct 28 Interleukin-6 Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells Takabayashi T, Vannier E, Burke JF, Tompkins RG, Gelfand JA, Clark BD. J Infect Dis. 177 :1622-8, 1998 Central role of interleukin-6 in burn-induced stimulation of hepatic amino acid transport Pawlik TM, Carter EA, Bode BP, Fischman AJ, Tompkins RG. Int J Mol Med. 2003 Oct;12(4):541-8 Kinase A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J. J Biol Chem. 2003 Sep 12;278(37):34897-909 Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Kyriakis JM, Avruch J. Physiol Rev. 2001 Apr;81(2):807-69 Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF. Recent Prog Horm Res. 2001;56:127-55 Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J. Biochem J. 2004 Jul 15;381(Pt 2):453-62 S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance Yasukawa T, Tokunaga E, Ota H. Sugita H, Martyn JA, Kaneki M J Biol Chem. 280(9):7511-8, 2005 Mar 4. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity Avruch J, Belham C, Weng Q, Hara K, Yonezawa K. Prog Mol Subcell Biol. 2001;26:115-54 Lipolysis A unique mechanism of desensitization to lipolysis mediated by beta3-adrenoceptor in rats with thermal injury Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA. Am J Physiol. 277 :E316-24, 1999 Liver Cutaneous burn injury alters relative tricarboxylic acid cycle fluxes in rat liver Yarmush DM, MacDonald AD, Foy BD, Berthiaume F, Tompkins RG, Yarmush ML. J Burn Care Rehabil. 20(4):292-302, 1999 TCA cycle flux estimates from NMR- and GC-MS-determined [13C]glutamate isotopomers in liver Vogt JA, Yarmush DM, Yu YM, Zupke C, Fischman AJ, Tompkins RG, Burke JF. Am J Physiol. 272 :C2049-62, 1997 Technique for expanding the donor liver pool: heat shock preconditioning in a rat fatty liver model Mokuno Y, Berthiaume F, Tompkins RG, Balis UJ, Yarmush ML. Liver Transpl. 2004; 10(2):264-72 Metabolism A rabbit model for metabolic studies after burn injury Hu RH, Yu YM, Costa D, Young VR, Ryan CM, Burke JF, Tompkins RG. J Surg Res. 75 :153-60, 1998 Efectos metabólicos del trauma y el traumatismo térmico: implicaciones en las necesidades calóricas Tredget EE, Yu Y-M. In: Lorente JA, Esteban A. eds. Cuidados intensivos del paciente quemado. Barcelona: Spinger-Verlag Ibérica 1998; pp. 199-234 Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model Yokoyama T, Banta S, Berthiaume F, Nagrath D, Tompkins RG, Yarmush ML Metab Eng. 7(2):88-103, 2005 Mar. In vivo rabbit hindquarter model for assessment of regional burn hypermetabolism Xu J, Fei Z, Yu YM, Xu W, Rhodes A, Tompkins RG, Schulz JT. J Appl Physiol. 94 :135-40, 2003 The metabolic basis of the increase of the increase in energy expenditure in severely burned patients Yu YM, Tompkins RG, Ryan CM, Young VR. JPEN 23:160-8, 1999 Metabolic alterations in muscle of thermally injured rabbits, measured by positron emission tomography Carter EA, Tompkins RG, Hsu H, Christian B, Alpert NM, Weise S, Fischman AJ. Life Sci. 61 :39-44, 1997 Metabolism 2000: the emperor needs new clothes Young VR, Ajami AM. Proc Nutr Soc. 60:27-44, 2001 Studying amino acid and protein metabolism in burn and other trauma patients. in El-Khoury AE ed. Methods for Investigation of Amino Acid and Protein Metabolism Yu Y-M, Ryan CM, Cai W. London: CRC Press LLC 1999. pp.211-230 Support of the metabolic response to burn injury Herndon DN, Tompkins RG. Lancet 2004 Jun 5;363(9424):1895-902 What's new in burns and metabolism? Sheridan RL, Tompkins RG. J Am Coll Surg. 2004 Feb;198(2):243-63 Mitochondrial Syndromes Burn injury causes mitochondrial dysfunction in skeletal muscle Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA Proc Natl Acad Sci U S A. 102(15):5368-73, 2005 Apr 12. Myocardial flow regulation in people with mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes/myoclonic epilepsy and ragged red fibers and other mitochondrial syndromes Tawakol A, Sims K, MacRae C, Friedman JR, Alpert NM, Fischman AJ, Gewirtz H. Coron Artery Dis. 14 :197-205, 2003 Mivacurium Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury Martyn JA, Goudsouzian NG, Chang Y, Szyfelbein SK, Schwartz AE, Patel SS. Anesthesiology. 92:31-7, 2000 Muscle Metabolism and Function Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats Yasuhara S, Kanakubo E, Perez ME, Kaneki M, Fujita T, Okamoto T, Martyn JA. The 1999 Moyer award. J Burn Care Rehabil. 20 :462-70, 1999 Disparate dysfunction of skeletal muscles located near and distant from burn site in the rat. Ibebunjo C. Martyn J. Muscle & Nerve. 24(10):1283-94, 2001 Oct Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine: effects of transamination and transmethylation Carter EA, Yu YM, Alpert NM, Bonab AA, Tompkins RG, Fischman AJ. J Trauma. 47 :341-5, 1999 Muscle protein synthesis by positron-emission tomography with L-[methyl-11C] methionine in adult humans Fischman AJ, Yu YM, Livni E, Babich JW, Young VR, Alpert NM, Tompkins RG. Proc Natl Acad Sci USA. 95 :12793-8, 1998 Nuclear DNA fragmentation and morphological alterations in adult rabbit skeletal muscle after short-term immobilization Smith HK, Maxwell L, Martyn JA, Bass JJ. Cell Tissue Res. 302:235-41, 2000 Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA FASEB J. 19(11):1431-40, 2005 Sep Skeletal muscle apoptosis after burns is associated with activation of proapoptotic signals Yasuhara S, Perez ME, Kanakubo E, Yasuhara Y, Shin YS, Kaneki M, Fujita T, Martyn JA. Am J Physiol Endocrinol Metab. 279:E1114-21, 2001 Myopathy A new twist to myopathy of critical illness Martyn JA, Vincent A. Anesthesiology. 91(2):337-9, 1999 Myostatin Gene The myostatin gene is a downstream target gene of basic helix-loop-helix transcription factor MyoD Spiller MP, Kambadur R, Jeanplong F, Thomas M, Martyn JK, Bass JJ, Sharma M. Mol Cell Biol. 22:7066-82, 2002 Necrolysis Long-term consequences of toxic epidermal necrolysis in children Sheridan RL, Schulz JT, Ryan CM, Schnitzer JJ, Lawlor D, Driscoll DN, Donelan MB, and Tompkins RG. Pediatrics. 109:74-8, 2002 Neurotransmitters A novel method for noninvasive detection of neuromodulatory changes in specific neurotransmitter systems Alpert NM, Badgaiyan RD, Livni E, Fischman AJ. Neuroimage. 2003 Jul;19(3):1049-60 Nitrogen Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults Rand WM, Pellett PL, Young VR. Am J Clin Nutr. 77:109-27, 2003 Plasma L-5-oxoproline carbon and nitrogen kinetics in healthy young adults Metges CC, Yu YM, Cai W, Lu XM, Wong S, Ajami AM, Young VR. J Nutr 129 :1998-2004, 1999 Outcomes Long-term outcome of children surviving massive burns Sheridan RL, Hinson MI, Liang MH, Nackel AF, Schoenfeld DA, Ryan CM, Mulligan JL, Tompkins RG. JAMA 283:69-73, 2000 Objective estimates of the probability of death from burn injuries Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG. N Engl J Med. 338 :362-6, 1998 Pancreatitis Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol Werner J, Saghir M, Warshaw AL, Lewandrowski KB, Laposata M, Iozzo RV, Carter EA, Schatz RJ, Fernandez-Del Castillo C. Am J Physiol Gastrointest Liver Physiol. 283:G65-73, 2002 Pediatric Burn Injury Body water in children during recovery from severe burn injury using a combined tracer dilution method Prelack K, Dwyer J, Sheridan R, Yu YM, Lydon M, Petras L, Dolnikowski G, Kehayias JJ J Burn Care Rehabil. 26(1):67-74, 2005 Jan-Feb. Long-term consequences of toxic epidermal necrolysis in children Sheridan RL, Schulz JT, Ryan CM, Schnitzer JJ, Lawlor D, Driscoll DN, Donelan MB, and Tompkins RG. Pediatrics. 109:74-8, 2002 Long-term outcome of children surviving massive burns Sheridan RL, Hinson MI, Liang MH, Nackel AF, Schoenfeld DA, Ryan CM, Mulligan JL, Tompkins RG. JAMA 283:69-73, 2000 Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury Martyn JA, Goudsouzian NG, Chang Y, Szyfelbein SK, Schwartz AE, Patel SS. Anesthesiology. 92:31-7, 2000 Sodium bromide by instrumental neutron activation analysis quantifies change in extracellular water space with wound closure in severely burned children Prelack K, Sheridan R, Yu YM, Stamatelatos IE, Dwyer J, Dallal GE, Lydon M, Petras L, Kehayias JJ. Surgery. 2003 Apr;133(4):396-403 Positron Emission Tomography (PET) Does whole-body 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography have an advantage over thoracic positron emission tomography for staging patients with lung cancer? Aquino SL, Fischman AJ. Chest. 2004 Sep;126(3):755-60 Mapping of local renal blood flow with PET and H215O Alpert NM, Rabito CA, Correia DJ, Babich JW, Littman BH, Tompkins RG, Rubin NT, Rubin RH, Fischman AJ. J Nucl Med 43:470-5, 2002 Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine: effects of transamination and transmethylation Carter EA, Yu YM, Alpert NM, Bonab AA, Tompkins RG, Fischman AJ. J Trauma. 47 :341-5, 1999 Metabolic alterations in muscle of thermally injured rabbits, measured by positron emission tomography Carter EA, Tompkins RG, Hsu H, Christian B, Alpert NM, Weise S, Fischman AJ. Life Sci. 61 :39-44, 1997 Muscle protein synthesis by positron-emission tomography with L-[methyl-11C]methionine in adult humans Fischman AJ, Yu YM, Livni E, Babich JW, Young VR, Alpert NM, Tompkins RG. Proc Natl Acad Sci USA. 95 :12793-8, 1998 Regional measurement of canine skeletal muscle blood flow by positron emission tomography with H215O Fischman AJ, Hsu H, Carter EA, Yu YM, Tompkins RG, Guerrero JL, Young VR, Alpert NM. J Appl Physiol 92:1709-16, 2002 Trends in tracer techniques, including use of positron emission tomography Young VR, Borgonha S, Ajami AM. Diabetes Nutr Metab. 13:35-45, 2000 Who should read and interpret 18F-FDG PET studies? Fischman AJ, Thrall JH. J Nucl Med. 2003; 44(8):1197-9 Posttraumatic Stress Disorder Hippocampal function in posttraumatic stress disorder Shin LM, Shin PS, Heckers S, Krangel TS, Macklin ML, Orr SP, Lasko N, Segal E, Makris N, Richert K, Levering J, Schacter DL, Alpert NM, Fischman AJ, Pitman RK, Rauch SL. Hippocampus. 2004;14(3):292-300 Proteins Radionuclide imaging probes for expressed proteins Fischman AJ. J Nucl Cardiol. 6(4):438-48, 1999 Pseudomonas aeruginosa Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication Deziel E, Lepine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1339-44 Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors Tan MW, Rahme LG, Sternberg JA, Tompkins RG, Ausubel FM. Proc Natl Acad Sci U S A. 96 :2408-13, 1999 Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM. Proc Natl Acad Sci USA. 25;94:13245-50, 1997 Q-TOF A new approach for sequencing human IRS1 phosphotyrosine-containing peptides using CapLC-Q-TOF(micro) Lu XM, Lu MY, Fischman AJ, Tompkins RG J Mass Spectrom. 40(5):599-607, 2005 May Site-specific detection of S-nitrosylated PKB alpha/Akt1 from rat soleus muscle using CapLC-Q-TOF(micro) mass spectrometry Lu XM, Lu M, Tompkins RG, Fischman AJ, J Mass Spectrom. 40(9):1140-8, 2005 Sep Rocuronium Neuromuscular pharmacodynamics of rocuronium in patients with major burns Han T, Kim H, Bae J, Kim K, Martyn JA. Anesth Analg. 2004 Aug;99(2):386-92 Sodium Bromide Sodium bromide by instrumental neutron activation analysis quantifies change in extracellular water space with wound closure in severely burned children Prelack K, Sheridan R, Yu YM, Stamatelatos IE, Dwyer J, Dallal GE, Lydon M, Petras L, Kehayias JJ. Surgery. 2003 Apr;133(4):396-403 Stavudine Preparation and pharmacokinetics of 11C labeled stavudine (d4T) Livni E, Berker M, Hillier S, Waller SC, Ogan MD, Discordia RP, Rienhart JK, Rubin RH, Fischman AJ. Nucl Med Biol. 2004 Jul;31(5):613-21 [top]